Located in Ashville, North Carolina, the 8000 acre Biltmore Estate is home to the largest privately owned house (179K square feet!) in the United States. Opened to the public in 1930 by the Vanderbilt's, this remnant of the Gilded Age remains a prominent tourist attraction. While the house itself is not open to overnight guests, a 210 room inn and historic cottage are. Plenty to fill up your weekend--touring the Vanderbilt estate, meandering through 75 acres of exquisite gardens, or a tasting at the Biltmore's own winery. And if you've something more low-key in mind, the hotel has a luxurious spa that has been fashioned after the main house where you can easily indulge any remaining 'other half' fantasies.